MRS. HOFFMAN'S PLTW MEDICAL INTERVENTIONS CLASS
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  • UNIT 1
  • UNIT 2
  • UNIT 3
  • UNIT 4
  • DNA & GENOMICS REVIEW
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UNIT 1: How to Fight Infection


1.1 - The Mystery Infection
1.1.1 Medical Interventions
  • ​Medical Interventio​ns: Color Changing Band-aid
  • Science: 2015 Breakthrough of the year
  • Types of Medical Interventions

1.1.2 Investigating an Outbreak​
  • RadioLab: Patient Zero Podcast
  • Video Animation of a Cell​
  • Controlling an Outbreak
  • Game: ​CDC Solve the Outbreak!

1.1.3 Identifying Pathogens​
  • What is a BLAST?
  • BLAST search
  • What is PCR?
  • PCR technique explained
  • ​PCR In more detail, step by step
  • PCR Video Explanation
  • PCR Video of Steps
  • Learn.Genetics: PCR Simulation
  • DNA Learn Center: DNA Sequencing
  • Essential Biochemistry Animation: DNA Sequencing
  • Video: Sanger Method of DNA Sequencing
  • Interactive: Sanger Method

1.1.4 Concentrations​
  • How to Do Serial Dilutions
  • Serial Dilution Animation & Video

1.1.5 ELISA
  • Cells of the Immune System
  • What is the Antigens-Antibody Complex?
  • Antigens & Antibodies: Detailed Overview
  • Antibody Interaction: Video
  • Immune System Overview
  • B Cell Activation Video
  • B and T Cell Overview
  • B and T Cell: In Depth (Khan Academy)
  • The Immune Response: Video
  • Immune Response Animation Video
  • Video: What is ELISA?
  • BioRad: ELISA Antibody and Antigen Detection
  • McGraw-Hill: ELISA video and quiz
  • Immunology: ELISA Intro and Explanation
  • ELISA Overview: Types of ELISA Explained
  • BioMedHead: ELISA Resources
  • hCG Elisa explanation
  • TedED: Home Pregnancy Test explanation
  • BBC: Defending against infection
  • Bio Crash Course: Your Immune System- Natural Born Killer
  • Bacterial Infection: Immune System Explained

1.2 - Antibiotic Treatment

1.2.1 Antibiotic Therapy
  • CellsAlive! Bacterial Structure Interactive
  • Bacterial Cell Structure & Function
  • Northern Illinois University: Bacterial structure ppt
  • Bacterial Plasmids Detailed Explanation
  • Biotech Learning Hub: The Role of Plasmids 
  • Gram Positive vs. Gram Negative: Video Explanation
  • Endotoxin vs. Exotoxin
  • History of Antibiotics
  • Antibiotic Attack!
  • Video: History of Penicillin
  • Microbiological Techniques
  • How to Put Bacteria on a Petri Dish
  • Aseptic Technique: Video
  • How antibiotics kill bacteria & not human cells
  • Antibiotics Mode of Action
  • TedEd: What causes Antibiotic Resistance?


1.2.3 Super Bugs!
  • Cipro on the Farm: Animation of Antimicrobial Resistance​
  • WHO: Antimicrobial Resistance
  • The Golden Age of Antibacterials: Timeline
  • Nature Article: Antibiotic Resistance, The Last Resort
  • Consumer Reports: The Rise of the SuperBugs
  • CBS: 15 Superbugs & Diseases
  • McGraw-Hill: Bacteria Conjugation Animation; ​Animation #2
  • Plasmid Replication: Rolling Circle Mechanism Video
  • Pearson: Bacterial Transformation
  • McGraw-Hill: Bacterial Transformation Animation
  • McGraw-Hill Generalized: Bacterial Transduction
  • American Society of Microbiology Animation: Transduction Animation
  • DNA Learning Center: DNA Transformation
  • Sulfonamide Antibiotic: PABA Explanation
  • Targets of Antibiotics

1.2.4 Antibiotics & Antibiotic Failure
  • Learn.Genetics: What is an Antibiotic?
  • How Antibiotics Work: Video
  • TED Video: What Causes Antibiotic Resistance?
  • How Antibiotics Work: Explanation and History
  • Antibiotic Attack Animation​
  • Article: An Alternative to Antibiotics
  • CDC 2013: Antibiotic Resistant Threats
  • FDA: Combating Antibiotic Resistance
  • How antibiotics target bacterial cells and not human cells
  • How Penicillin Kills Bacteria (watch video)
  • Class of Antibiotic Most Effective Against Gram Neg Bacteria

1.3 - The Aftermath - Hearing Loss

1.3.1 Good Vibrations
  • Ear Diagram: Interactive
  • How the Ear Hears
  • Hearing Structures & Functions
  • Label the Ear practice
  • Sound Properties

1.3.2​ Can You Hear Me Now?
  • Hearing Test: Can You Hear This?
  • Hearing Loss
  • Conductive Hearing Loss
  • Bone Conduction
  • How Bone Conducting Headphones Work
  • Try it: Hearing Test
  • The Rinne Test
  • Understanding an Audiogram
  • How to read an Audiogram Explanation
  • Hearing Loss (types, explanation, causes)
  • How does hearing work?

1.3.3 Cochlear Implant Debate
  • How the Ear Works & Hearing Loss
  • Cochlear Implants
  • Hearing Aids
  • An example of hearing loss video
  • 3 types of hearing loss video
  • Do I really sound like that?
  • How old are your ears?
  • Scientific American: Hearing Aids Meet the Future with Bluetooth

1.4 - Vaccination
1.4.1 Vaccinations
  • History of Vaccines: How Vaccines Work
    • Different Types of Vaccines Explanation
    • Types of Vaccines Visual
    • How Vaccines are Made
    • Herd Immunity Animation
  • CDC: Vaccines
  • History of Vaccines: Edward Jenner 100 greatest discoveries

1.4.2 Vaccine Development
  • Vaccines.org: Types of Vaccines
  • DNAi: Recombinant DNA Review
  • Antiviral Development
  • Vaccines Given by Age
  • Making vaccines video
  • WHO: Immune Response to Vaccinations
  • Vaccines by Sound Waves 
  • Vaccination Debate: Part I; Part II
  • Science Video: The riskiest vaccine? The one not given
  • Vaccines do not cause Autism
  • Data Falsification of Vaccines
  • DNA Ligase
  • Review of Restriction Enzymes
  • How Recombinant DNA Works
Vaccine Debate:
  • Vaccine Schedule by State w/Ingredients


1.4.3 Epidemiologist
  • Roles & Responsibilities
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UNIT 2: Screen What's in Your Genes


2.1 - Genetic Testing & Screening
2.1.1 Chronicles of a Genetic Counselor
  • ​Genetic Counseling
  • ​NOVA: Testing Tay Sachs Video

2.1.3 Testing YOUR Genes
  • PCR Animation
  • Learn. Genetics Making SNP's Make Sense
  • DNA Learning Center: PCR Animation
  • PTC Taste & Genes

2.1.5 Maternal Testing
  • Amniocentesis
  • CVS
  • Prenatal Screening Risks & Benefits
  • Karyotype and Genetic Disorders
  • Karyotype Examples
  • Using a Karyotype to Diagnose Disorders

2.2 - Our Genetic Future
2.2.1 Gene Therapy
  • What is Gene Therapy?
  • Gene Therapy: Space Doctor
  • Learn. Genetics Gene Delivery Vectors
  • BBC: Designer Baby Debate
  • Genetic Ethics​

2.2.2​ Reproductive Technology
  • Reproductive Cloning
  • National Geographic Video: Clone​
  • Therapeutic Cloning​
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UNIT 3: How to Conquer Cancer


3.1 - Detecting Cancer
3.1.1 Who is affected by cancer?
  • NIH: What is cancer?
  • ​Cancerous Cells
  • Cells Behaving Badly
  • Causes of Cancer
  • Microscopic Appearance of Cancer Cells

3.1.2 Diagnostic Imaging
  • ​Cancer Treatment Diagnostic Imaging Videos:
    • ​X-Ray
    • CT Scan
    • MRI
    • Bone Scan
    • Biopsy
    • PET Scan
  • Differences between X-ray, CT and MRI
  • Cancer Diagnostic Tests

3.1.3 When Cells Lose Control
  • ​Metatasis (view slideshow @ bottom of the screen)
  • Apoptosis
    • Cells Alive video "Dance of Death"
    • Apoptosis Animation Video
  • HeLa cells
  • Cellular Division
  • How cancer cells divide
  • Transformation from normal to cancer cells
  • Proto-oncogenes vs. Oncogenes
  • Tumor supressor cells/gen​es

3.1.4 Microarray
  • ​p53 Role in the cell
  • Intro to DNA Microarrays with Animation
  • Making a Microarray: Explanation video
  • DNA Microarray Simulation
  • HHMI: How to Analyze Microarray Data
  • Learn. Genetics: Microarray Simulation

3.1.5 Gene Expression
  • Gene Expression
    • Short explanation with video​

Eukaryotic Gene Expression
  • DNA Methylation vs. Histone Acetylation
  • Khan Academy Eukaryotic Gene Regulation
  • Agouti Mice Epigenetics
  • What is Epigenetics? Video
  • Transcription Animation
  • Enhancer Explanation and Animation/Quiz
  • Post-transcriptional Control
  • Post-translational Modifications - Khan Academy
  • Gene Expression Animation
Using Bioinformatics: Gene Expression
  • cDNA Libraries
  • NCBI
  • Ensembl
  • UCSC Genome Browser
  • Encyclopedia of DNA Elements (ENCODE  Project)
  • VISTA

3.2 - Reducing Cancer Risk
3.2.1​ Risk Factors
  • Risk factors for Cancer
  • The Genetics of Cancer
  • National Cancer Institute: Causes & Prevention Research
  • Cancer Prevention
  • Marker Analysis
  • Short Tandem Repeats Video

3.2.2 Yeast Cells (Skin Cancer)
  • Suspicious moles
  • Skin Cancer:
    • ABCDE
    • Melanoma

3.2.3 Breast Cancer
  • ​Treatment
  • Risk Factors
  • Video: BCRA Gene Dr. Seuss
  • Double Mastectomy: Angelina Jolie

3.2.4 Virology
  • American Society of Virology

3.2.5 Scanning
  • Cancer.org: Cancer Screening
  • CDC: Cancer Screening Tests
  • Early Detection & Screening for Breast Cancer
  • Cancer Prevention: Mammograms
  • Cancer Screening Guideline​

3.3 - Treating Cancer
3.3.1 Cancer Diary
  • BBC: Harnessing the Immune System to Fight Cancer
  • American Cancer Society: Chemotherapy
  • Chemotherapy Cooling Cap to Prevent Hair Loss
  • NIH: Radiation Therapy
  • A Guide to Radiation Therapy
  • Cancer Treatment Video
  • Radiation Therapy to Treat Cancer Video
  • Giving Viruses a License to Kill Cancer Video
  • Chemotherapy Medical Animation
  • Cancer Survivor Explains Rotationplasty​

3.3.2 Biofeedback
  • Biofeedback Effects of Stress: Methods on how to Relax
  • Online Relaxation Exercises

3.3.3 Prosthetic Arm
  • Prosthetic Arm:
    • bebionic
    • Hopkins Applied Physics Lab 
    • Quartz Prosthetic Robot Arm
  • Deka Arm
    • Video
  • The Bionic Man video

3.3.4 Physical & Occupational Therapy
  • Physical Therapy
  • Occupational Therapy

3.4 - Building a Better Cancer Treatment
3.4.1 Personalized Medicine
  • Personalized medicine
  • Learn. Genetics: Pharmacogenetics
  • Learn.Genetics: Prescision Medicine

3.4.2 Nanofuture
  • TEDTalks: Future of Medicine
  • Respirocytes
    • Definition

3.4.3 Clinical Trials
  • Medline: Clinical trials
  • NIH Clinical Trials

3.4.4 Tiny Treatment
  • Nanotechnology tricking cancer cells
  • Video: Nanotechnology with Stephen Fry
  • Nanomedicine to Fight Cancer: Video
  • Science Jan 2017: Nanoparticles awaken immune cells to fight cancer
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UNIT 4: Prevail When Organs Fail


4.1 - Manufacturing Human Proteins
  • Recombinant DNA with Insulin
  • Article: Bacteria are Genetically Modified by Lightning
  • DNA Transformation
  • pGLO Transformation Guide
  • BioRad pGLO Tranfsormation and Protein Purification ppt
  • Chromatography
  • Animation: Protein Chromatography
  • Protein Purification by Chromatography Video Explanation
  • Amino Acid Structures
  • Protein Folding Explanation
  • Help Standford: Protein Folding ID 
  • Protein Folding Interactive
  • Protein electrophoresis Animation
  • Pearson Protein Structure Animation
  • Video: SDS Gel Electrophoresis
  • SDS Page Step by Step Animation
    • Biology Animation #2

4.2 - Organ Failure
  • Normal Blood Levels
  • Urinalysis
  • ERSD

4.3 - Transplant
  • Blood Groups & Typing
  • Blood Typing Explanation & Practice: A, B, O Analysis
  • HLA Testing
  • PRA 
  • Laproscopy
  • Minimally Invasive Surgery
  • Laproscopic Surgery: How its Performed
  • ​Basic Suturing Technique Video
  • Simple Interrupted Suture Video

4.4 - Building a Better Body
  • Bionic Human
  • Bionic Spine Video
  • The Six Million Dollar Man
  • 08/01/15: Blind woman gets a Bionic eye
  • How the bionic eye works
  • Interactive: Organ transplants
  • Tissue engineering
  • Tissue regeneration
  • Xenotransplantation
  • Would you accept a pig organ to save your life?
  • Nature article: The boom in mini-organs 
  • The Economist: Organ printing
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DNA REVIEW

DNA STRUCTURE:
  • BioMedHead: DNA Review
  • DNA Structure YouTube Video
  • DNA Structure Explained
  • Khan Academy: DNA Molecular Structure Video
  • Science: 3D Chromatin Structure & Visualization

DNA REPLICATION:
  • Khan Academy: Leading & Lagging Strand Video Review
  • Khan Academy: DNA Replication Step-by-Step Explanation
  • DNA Polymerase & Replication: video
  • McGraw-Hill DNA Replication Fork animation
  • McGraw-Hill DNA Replication w/Quiz
  • DNA Replication Video
  • DNA Replication Video #2
  • Amoeba Sisters: DNA Rep

PCR (Polymerase Chain Reaction):
  • What is PCR?
  • PCR Video Animation
  • PCR 3-D Animation
  • Cold Spring Harbor Interactive
  • HHMI PCR Interactive
  • Khan Academy PCR Video
  • Khan Academy PCR Explanation

PROTEIN SYNTHESIS:
  • Khan Academy: Transcription & mRNA processing
  • Protein Synthesis Overview Interactive
  • McGraw-Hill Animation: mRNA Synthesis
  • ​​HHMI Transcription Basic Video
  • ​HHMI Transcription Advanced Video
  • HHMI Translation video
  • **Learn Genetics DNA, Genes & Proteins Animations​

GENOMICS REVIEW

GENES:
  • Genetics Home Reference: Genome Explanation
  • 23andMe: Genes
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​GENE EXPRESSION:
  • Gene Suppression/Silencing
  • Recombinant DNA Explanation
  • Learn.Genetics: Measuring Gene Expression
  • Alternative Gene Splicing w/Spliceosomes Video
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About Mrs. Hoffman

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Website created August 2015 by K.Hoffman
Mrs. Hoffman's other websites:
GHS PLTW Biomedical Science Website: pltwghs.com
PLTW Human Body Systems (HBS) Website: hoffmanheartshbs.com
PLTW/Honors Biology Website: yoloinbiology.com
AP Environmental Science (APES) Website: 
hoffmangoesapes.weebly.com
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